Table 4.
Predictors of higher EULAR response and disease remission in PsA cohort at 6 months
| Variable | Higher EULAR response, OR (95% CI) | Disease remission, OR (95% CI) | ||
|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |
| Demographic variables | ||||
| Age at start of therapy | 0.98* (0.96, 0.99) | 0.97* (0.95, 0.99) | 0.97* (0.95, 0.99) | 0.96* (0.94, 0.99) |
| Female | 0.49* (0.35, 0.70) | 0.51* (0.34, 0.78) | 0.37* (0.25, 0.55) | 0.34* (0.21, 0.57) |
| Smoking (yes/no) | 0.96 (0.68, 1.36) | 1.07 (0.71, 1.59) | 0.76 (0.51, 1.14) | 0.74 (0.45, 1.20) |
| Baseline co-morbiditya (yes/no) | 0.88 (0.60, 1.29) | 0.83 (0.53, 1.30) | 0.77 (0.51, 1.16) | 0.64 (0.38, 1.06) |
| Disease variables | ||||
| Baseline DAS-28 | 1.01 (0.99, 1.02) | 0.99 (0.98, 1.02) | 0.99 (0.98, 1.01) | 0.99 (0.96, 1.02) |
| Baseline HAQ | 0.78* (0.62, 0.98) | 0.85 (0.66, 1.08) | 0.78 (0.59, 1.03) | 0.85 (0.63, 1.15) |
| Disease duration (years) | 1.01 (0.99, 1.03) | 1.02 (0.99, 1.04) | 0.99 (0.97, 1.02) | 1.00 (0.97, 1.04) |
| Inflammationb | 0.54* (0.30, 0.96) | – | 0.54* (0.31, 0.97) | – |
| TJC | 1.00 (0.98, 1.03) | – | 0.97 (0.95, 1.00) | – |
| SJC | 1.01 (0.99, 1.05) | – | 0.99 (0.95, 1.02) | – |
| Therapeutic variables: concurrent use of | ||||
| DMARDs | 1.31 (0.42, 4.06) | 0.82 (0.19, 3.55) | 0.42 (0.09, 1.93) | 0.44 (0.05, 4.18) |
| Steroids | 0.48* (0.31, 0.74) | 0.45* (0.28, 0.72) | 0.57 (0.32, 1.01) | 0.55 (0.29, 1.02) |
| Biological therapy: etanercept is the reference category | ||||
| Infliximab | 0.55 (0.37, 1.82) | 0.60 (0.38, 1.95) | 0.57 (0.35, 1.94) | 0.69 (0.39, 1.22) |
| Adalimumab | 1.01 (0.63, 1.63) | 0.81 (0.44, 1.49) | 1.16 (0.67, 1.99) | 0.97 (0.46, 2.04) |
*P < 0.05.
aIncludes any of hypertension, angina, ischemic heart disease, stroke, pulmonary fibrosis, asthma, chronic obstructive pulmonary disease, diabetes, thyroid disease, peptic ulcers, hepatic disease, renal disease, demyelinating disease, epilepsy, depression, TB and cancer. bInflammation (CRP > 20 mg/l or ESR > 28 mm/h). SJC: swollen joint count; TJC: tender joint count.