Figure 2.

ABT-510 alters tumor vasculature. Ovarian tumors were collected from mice treated with vehicle or ABT-510 60 days after tumor induction. ABT-510 caused a significant decrease in blood vessel density (A) and tumor vessel area (B). (C) ABT-510 treatment resulted in more pericyte covered blood vessels, as evidenced by positive staining for CD31 and SMA. (D) Quantification of the percentage of mature, pericyte-covered blood vessels. Bars with asterisks are statistically different (P < .05) compared with D5W-treated controls.