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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Nat Chem Biol. 2009 Oct 25;5(12):913–919. doi: 10.1038/nchembio.242

Figure 4.

Figure 4

Curlicide inhibition of UTI89 amyloid-dependent and type 1 pili-dependent biofilm formation on PVC. (a) Curli were dispensable for UTI89 biofilm formation in LB but were required for YESCA-grown biofilms. (b) UTI89 biofilm formation in YESCA in 96-well PVC plates was inhibited in the presence of curlicides, as quantified by crystal violet staining35. (c) FN075 inhibited UTI89 biofilm formation on PVC in LB in a dose-dependent manner. Percent biofilm inhibition represents the decrease in biofilm formation in the presence of curlicide relative to biofilm formation when no compound was present. Bars in b and c represent s.d. of the mean of four experiments, where controls with no compound were included in each experiment on each plate. No effects on bacterial growth rate were observed at these compound concentrations (Supplementary Fig. 2).