Skip to main content
. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Nat Chem Biol. 2009 Oct 25;5(12):913–919. doi: 10.1038/nchembio.242

Figure 5.

Figure 5

FN075 attenuation of virulence in vivo. (a) Curli mutants, UTI89ΔcsgBG and UTI89ΔcsgA, were significantly attenuated in bladder colonization compared to UTI89, as determined by CFU counts (P < 0.007 and P < 0.011, respectively, as determined by a two-tailed Mann Whitney for each mutant–wild-type pair). Geometric means are indicated by solid lines. (b) FN075 (2) reduced virulence of UTI89 in the mouse model of urinary tract infection. Bacteria were grown in the presence of 250 μM FN075 and then introduced into bladders of 7- to 8-week-old female C3H/HeN mice by a single transurethral inoculation of 1–2 × 107 CFU. FN075-treated cells exhibited more than a 10-fold decrease in CFU/bladder at 6 hpi (P < 0.0001, two-tailed Mann-Whitney test) and produced significantly fewer IBCs than nontreated bacteria (P < 0.0001).