Scheme 1.

Schematic representation of induced H₂O₂ selectivity by encapsulating DCFDA into relatively hydrophobic Ormosil nanoparticles. The left scheme shows that DCFH (activated form) can be oxidized by a variety of interferents. The right scheme shows that a relatively hydrophobic nanoparticle matrix encapsulating DCFDA (precursor form) can filter the interferences, thus only allowing penetration of H₂O₂, resulting in high selectivity towards this specific analyte.