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. Author manuscript; available in PMC: 2010 Oct 16.
Published in final edited form as: Biochem Biophys Res Commun. 2009 Aug 11;388(2):450–455. doi: 10.1016/j.bbrc.2009.08.042

Fig. 4.

Fig. 4

The γ-secretase inhibitor DAPT did not affect cell death induced by C31 expression. (A) Western blot showing no substantive change in APP processing as seen by immunoblotting with 6E10 and CT 15 antibodies. The levels of C-terminal fragment markedly increased following exposure to DAPT. (B) The ethidium homodimer staining showed substantial cell death after co-expression of C31 and APP that were unchanged after DAPT treatment. Expression of APP-D664A in place of wild type APP resulted in an absence of cytotoxicity that was not affected by DAPT treatment. (*p < 0.001).