Table 3.
Hazard ratios (HR) for incident all-cause dementia and Alzheimer’s disease according to sex-specific quartiles of baseline leptin levels
| All Cause Dementia | Alzheimer’s Disease | |||||
|---|---|---|---|---|---|---|
| Sex-specific quartiles of leptin | Events/persons at risk | HR (95% CI) | P | Events/persons at risk | HR (95% CI) | P |
| A. Adjusted for age and sex | ||||||
| Q1 | 42/196 | Referent | 38/196 | Referent | ||
| Q2 | 29/196 | 0.67 [0.42–1.08] | 0.100 | 23/196 | 0.60 [0.35–1.00] | 0.051 |
| Q3 | 23/196 | 0.52 [0.31–0.86] | 0.012 | 20/196 | 0.50 [0.29–0.65] | 0.011 |
| Q4 | 17/197 | 0.40 [0.23–0.71] | 0.002 | 8/197 | 0.21 [0.10–0.44] | <0.001 |
| Trend | <0.001 | <0.001 | ||||
| B. Adjusted for age, sex, plasma homocysteine in the top age-specific quartile, APO E-genotype | ||||||
| Q1 | 37/165 | Referent | 33/165 | Referent | ||
| Q2 | 27/158 | 0.86 [0.50–1.46] | 0.570 | 22/158 | 0.86 [0.48–1.54] | 0.613 |
| Q3 | 19/164 | 0.48 [0.26–0.87] | 0.016 | 17/164 | 0.52 [0.27–0.99] | 0.045 |
| Q4 | 12/154 | 0.42 [0.20–0.84] | 0.015 | 5/154 | 0.23 [0.08–0.61] | 0.003 |
| Trend | 0.003 | <0.001 | ||||
Abbreviations: Q, quartile; CI, confidence interval; HR, hazard ratio