. Author manuscript; available in PMC: 2010 Dec 16.

Published in final edited form as: JAMA. 2009 Dec 16;302(23):2565–2572. doi: 10.1001/jama.2009.1836

Table 5.

Association of sex-standardized log-leptin levels with MRI precursors of subclinical Alzheimer’s disease

	Total cerebral brain volume		Temporal horn volume

Model	β±SE	P	β±SE	P
A. Age- and sex-adjusted	0.76±0.26	0.004	−0.12±0.06	0.033
B. adjusting for basic risk factors^*	0.80±0.28	0.005	−0.08±0.06	0.181
C. Model B and vascular risk factors^†	0.88±0.31	0.005	−0.05±0.07	0.432
D. Model C plus CES-D scale	0.88±0.31	0.005	−0.05±0.07	0.437

Adjustment for age, sex, plasma homocysteine in the top age-specific quartile, APO E-genotype

^†

Adjustment for age, sex, plasma homocysteine in the top age-specific quartile, APO E-genotype, WHR, systolic blood pressure, antihypertensive treatment, diabetes, smoking, atrial fibrillation

Abbreviations: WHR, waist-to-hip ratio; APO E, apolipoprotein E; SE, standard error; CES-D, center for epidemiologic studies depression scale Regression coefficient β indicates the increase in total cerebral brain volume and temporal horn volume per one-SD increment in sex-standardized log-leptin.