Fig. 4.
Mechanisms of altered Isc as influenced by weaning age. A: jejunum from 35-day-old pigs that were early weaned (at 15 days of age) was mounted on Ussing chambers. After a 30-min equilibration period, normal Ringer solution was replaced with Cl−-free Ringer solution, and resultant changes in Isc were monitored. Data represent averages from 5 pigs and were analyzed using repeated-measures ANOVA. Treatments differed by P < 0.05; pooled SE value = 4.3. B: jejunum from late-weaned pigs (at 28 days of age) was treated with the K+ channel blocker BaCl2 on the mucosal surface, after which changes in Isc were monitored. Data represent averages from 5 pigs and were analyzed using repeated-measures ANOVA. BaCl2 treatment induced a positive deflection in Isc (P < 0.05).