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. 2009 Dec 8;298(3):E419–E428. doi: 10.1152/ajpendo.00417.2009

Fig. 5.

Fig. 5.

SIRT1 activator improves glucose intolerance and insulin sensitivity in obese Zucker rat. Body weight (A), average daily food intake (B), epididymal fat mass (C), and plasma glucose on ad libitum feeding (D) were measured after Zucker fa/fa rats were placed on normal chow diet (Zucker) or normal chow diet supplemented with SRT2379 at 100 mg per kg of body weight per day (Zucker + SRT) for 24 days (B–D) or indicated time periods (A; n = 6). E: glucose and insulin responses during an oral glucose tolerance test (OGTT) are shown after normal chow diet or normal chow diet with SRT2379 for 24 days (n = 6). G: Insulin sensitivity evaluated through the average glucose infusion rate at equilibrium in a hyperinsulinemic euglycemic clamp (25 mU insulin·kg·−1min−1) in Zucker fa/fa rat treated with or without SRT2379 for 4 wk (n = 4). *P < 0.05, Zucker vs. Zucker + SRT.