Table 2.

Animal characteristics of SIRT1(+/−) mice

	WT		SIRT1(+/−)
Parameters	Control	STZ	Control	STZ
Blood glucose, mg/dl	112 ± 10	402 ± 30*	120 ± 15	400 ± 60*
Serum insulin, ng/ml	1.32 ± 0.12	0.29 ± 0.1*	1.36 ± 0.26	0.22 ± 0.04*
Serum TG, mg /dl	29.5 ± 4.3	66 ± 6.8*	32 ± 3.5	79 ± 8.9*
Body wt, g	33.7 ± 3.9	23.1 ± 3.5*	29.4 ± 3.1	20.3 ± 1.1*
Heart wt, mg	144.9 ± 4.5	103.9 ± 5.3	131.7 ± 6.0	154.28 ± 8.7
HW/BW, 10−3	4.3 ± 0.1	4.5 ± 0.18	4.48 ± 0.19	7.6 ± 0.18*

Values are means ± SD of at least 6 animals in each group. SIRT1(+/−), Silent information regulator 1 knockout; WT, wild type; STZ, animals following 1 mo of streptozotocin injection.

^*Significant (P < 0.05) difference from non-STZ-injected control animals.