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Schematic representation depicts the targeting, in human embryonic kidney-293 (HEK-293) cells, of human TPC1 and chicken TPC3 to different endosome populations, and of human TPC2 to lysosomes, and the functional role of these acidic organelles. SOC and ROC, store- and receptor-operated channel, respectively; VGCC, voltage-gated Ca2+ channel; TGN, trans-Golgi network. [Adapted from Luzio et al. (62)].
