Table 1.
Percentage of MK displaying activity under control and experimental conditions in response to ADP and ATP 10 μM stimulation
| N | ADP (10 μM) |
ATP (10 μM) |
|||||
|---|---|---|---|---|---|---|---|
| OSC | SP | NR | OSC | SP | NR | ||
| Control | 28 | 60 | 27 | 13 | 62 | 23 | 15 |
| ASA (1 mM) | 35 | 83 | 11 | 6 | 53 | 41 | 6 |
Megakaryocytes (MKs) were studied by using the nystatin-perforated patch-clamp configuration. Holding potential (VH) = −40 mV. Control and experimental cells were stimulated with 10 μM ADP or 10 μM ATP. Cells were grouped according to agonist and response: OSC, oscillatory currents; SP, single-peak currents; NR, no response. ASA, acetylsalicylic acid. Values represent percent of total N cells.