Table 3.

Parameters of EUS EMG activity after serial administration of vehicle, 8-OH-DPAT, and WAY-100635 in urethane-anesthetized rats

	SP, s	AP, s	BD, s	TSP, s	BD/CD, %
Vehicle (n = 18)	0.14 ± 0.03	0.07 ± 0.01	4.60 ± 1.45	3.03 ± 1.01	21.05 ± 10.21
Agonist (8-OH-DPAT; 0.3 mg/kg)	0.23 ± 0.06*	0.08 ± 0.01	7.75 ± 1.54*	5.75 ± 1.31*	28.74 ± 9.25
Antagonist (WAY-100635; 0.1 mg/kg)	0.10 ± 0.02*†	0.08 ± 0.01	3.45 ± 2.10†	1.90 ± 1.15†	15.07 ± 5.87†

Values are means ± SE. EUS EMG, external urethral sphincter electromyogram. Silent (SP) and active period (AP) denote the average duration of quiescent and tonic EUS EMG activity during the bursting period shown in Fig. 2. TSP, total duration of the silent periods during each void; BD, bursting duration; CD, contraction duration.

^* P < 0.05 indicates a statistically significant difference compared with vehicle treatment (post hoc least significance difference test).

^† P < 0.05 indicates a statistically significant difference compared with 8-OH-DPAT treatment (post hoc least significance difference test).