Table 6.
VT, ml | Base, cmH2O | CA, cmH2O | CD, min | ICI, min | |
---|---|---|---|---|---|
Vehicle (n = 12) | 0.80 ± 0.29 | 14.77 ± 1.95 | 50.94 ± 5.70 | 0.62 ± 0.15 | 0.81 ± 0.20 |
Agonist (8-OH-DPAT; 0.3 mg/kg) | 0.33 ± 0.10* | 14.99 ± 3.73 | 58.03 ± 7.56* | 0.66 ± 0.23 | 0.68 ± 0.19 |
Antagonist (WAY-100635; 0.1 mg/kg) | 1.26 ± 0.31*† | 14.10 ± 2.68 | 42.86 ± 3.15*† | 0.65 ± 0.20 | 1.02 ± 0.16*† |
Values are means ± SE. Base: basal pressure; ICI: intercontraction interval.
P < 0.05 indicates a statistically significant difference compared with vehicle treatment (post hoc least significance difference test).
P < 0.05 indicates a statistically significant difference compared with 8-OH-DPAT treatment (post hoc least significance difference test).