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. 2009 Dec 23;298(3):F827–F837. doi: 10.1152/ajprenal.00683.2009

Fig. 15.

Fig. 15.

Effects of actinomycin D on HK-2 cell H2A.Z expression in the presence and absence of FeS. Under control incubation conditions, actinomycin D reduced H2A.Z expression at TNF, MCP-1, and TGF-β1 genes by approximately one-half. Actinomycin also significantly blunted the extent to which the Fe challenge raised H2A.Z expression at these 3 genes. Conversely, actinomycin failed to suppress control H2A.Z levels at the HO-1 gene, although there was a trend (P < 0.07) toward H2A.Z suppression in the presence of Fe.