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Time course of renal cortical transforming growth factor-β1 (TGF-β1) mRNA levels and Pol II binding to the TGF-β1 gene. Similar to TNF-α and MCP-1, TGF-β1 mRNA levels continued to increase over the 7 days after glycerol injection. Results were paralleled by progressive increases in Pol II binding to exon 1 of the TGF-β1 gene. Open bars, controls; solid bars, glycerol-treated mice.
