Fig. 4.

Time course of renal cortical heme oxygenase-1 (HO-1) mRNA expression and Pol II binding to the HO-1 gene. At 1 and 2 days after glycerol injection, HO-1 mRNA was markedly increased compared with control values. By day 7, mRNA levels had returned to control values. Increased Pol II binding was also observed at each time point. Unlike the Pol II binding results for TNF-α, MCP-1, and TGF-β1, no further increase in Pol II binding to the HO-1 gene was observed on day 7. Open bars, controls; solid bars, glycerol-treated mice. NS, not significant.