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Time course of H2A.Z and H3K4 methylation at exon 1 of the TGF-β1 gene. At each time point, a significant increase in H2A.Z and H3K4 methylation was observed in the glycerol-treated animals at the start exons of the TGF-β1 gene. Unlike TNF-α and MCP-1, increases at TGF-β1 reached maximal or near-maximal levels on day 1 and were not progressive thereafter. Open bars, controls; solid bars, glycerol-treated mice.
