FIG. 1.

(A) Basal tear production. Schirmer's test was performed on the right (OD) and left (OS) eyes as previously described⁶ on 22 rabbits (Day 0) and then stimulated lymphocytes were injected into the contralateral iLG to induce disease. Schirmer's test was repeated every 4 weeks (ID n = 6), induced disease with cyclosporine A (CsA) treatment (ID/Rx n = 9), and induced disease with Endura treatment (ID/E n = 7). An asterisk indicates a significant difference between the ID and ID/Rx animals. An α indicates a significant difference between ID/E and ID/Rx. The values were calculated using independent sample t-tests. (B) Tear breakup time. Tear breakup time demonstrates tear instability. Slit-lamp examination was performed in both groups before surgery (Day 0) and every 4 weeks postinjection. The group designations and statistical analysis were the same as in A. (C) Rose Bengal staining score. Detection of ocular surface defects on OD was evaluated with rose Bengal stain as previously described⁶; and the intensity of staining of the medial and lateral bulbar conjunctiva and the cornea was scored. The designations for groups and statistical analysis are the same as in A.