FIG. 4.

Immunohistochemical staining of cell markers. At 6 months more CD4⁺ T cells were detected in dense foci around iLG ducts and venules of untreated animals (A) than CsA-treated animals (B). CD8⁺ T cells were occasionally seen around ducts or venules of iLGs from untreated (C) compared to treated animals (D), but these cells were never abundant in either group. Areas with intense staining for MHC-II protein were more evident around venules and ducts, infiltrating into the interstitium around LG acini of untreated animals (E) and less in rabbits treated with cyclosporine (F). Fewer RTLA⁺ cells were seen in iLG of untreated animals (G) than in treated animals (H). Distribution of CD18 cells resembled that of RTLA cells in untreated (I) and treated (J) animals. There was no significant difference between the two groups in the total percentage of the CD18⁺ T cells.