Table 1.

Immunohistochemical Analysis of Inflammatory Cells in Lacrimal Glands With Induced Disease With and Without Cyclosporine Treatment

Group	CD4 (P < 0.004)	CD8 (P > 0.32)	MHC-II (P < 0.012)	RTLA (P < 0.005)	CD18 (P < 0.11)
Untreated (ID) mean positive percentage ± SD	4.41 ± 0.9	0.67 ± 0.2	8.5 ± 0.4	6.2 ± 0.9	8.7 ± 0.6
CsA-treated (ID/Rx) mean positive percentage ± SD	0.75 ± 0.2	0.39 ± 0.1	6.6 ± 0.5	11.4 ± 1.7	7.5 ± 0.4

Compared to ID group, the CsA-treated group (ID/Rx) had a significant decrease of CD4⁺ (P < 0.008), MHC-II (P < 0.012), and RTLA (P < 0.005), and no significant change in CD18⁺ (P < 0.11).