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. Author manuscript; available in PMC: 2010 Mar 15.
Published in final edited form as: Cancer Growth Metastasis. 2009 Aug 17;2:13–27. doi: 10.4137/cgm.s2814

Figure 1.

Figure 1

Fluorescence imaging of tumors with a protease-activated NIRF probe. A) A schematic diagram of probe activation. The initial proximity of the fluorochrome to each other results in signal quenching. B) Chemical structure of the probe. Green arrow indicates the enzymatic degradation site. C) Images of a LX-1 tumor implanted into the mammary fat pad of a nude mouse after probe injection. The arrow indicates the tumor. D) NIRF image (in red) superimposed onto the correlative phase contrast microscopy image of the excised tumor. Adapted from 26.