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. Author manuscript; available in PMC: 2010 Mar 15.
Published in final edited form as: Cancer Growth Metastasis. 2009 Aug 17;2:13–27. doi: 10.4137/cgm.s2814

Figure 3.

Figure 3

Bioluminescence imaging of protease activity in vivo. A) DEVD-luciferin, which is not a substrate for firefly luciferase (fLuc), becomes a fLuc substrate upon caspase-3/7 cleavage of the peptide. B) Left: A cartoon of the tumor implantation sites in mice. Dotted circle: a caspase-positive tumor. Center: The mouse was imaged for fLuc activity and tumor progression with D-luciferin injection. Right: Twenty-four hours later, the same mouse was injected with DEVD-luciferin and imaged. Note the different scale for the two images. Adapted from 65.