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Inhibition of SHP2 correlates with increased RhoA activity. Lysates from PAEC transfected with SHP2C459S or GFP (A and B) or from LMVEC monolayers treated with 100 μM NSC-87877 for 3 h (C and D) were incubated with GST-RBD (A and C) or GST-RhoGDI-1α (B and D) conjugated to agarose beads, and precipitates, in parallel with total lysates, were immunoblotted for RhoA. Data are presented as means ± SE; n = 3. *P < 0.05 vs. GFP or vehicle, respectively.
