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. 2010 Feb 19;11(3):180–186. doi: 10.1038/embor.2010.11

Figure 2.

Figure 2

The ADP binding site. (A) The DEAH-specific binding site for the adenine base between Arg 159 in RecA-1 and Phe357 in RecA-2. Water molecules are shown as red spheres. (B) Comparison of the nucleotide binding sites of a DEAH-box and DEAD-box (grey) helicase (Andersen et al, 2006). (C) Schematic representation of direct interactions between the ADP molecule and Prp43p. Dashed lines represent backbone interactions (eletrostatic or hydrogen bonds) and full lines represent side-chain interactions. The different motifs are shown in bold. (D) The interactions between ADPNP and eIF4AIII (DEAD-box helicase) are shown as in (C). The DEAD-box specific Q motif is responsible for direct recognition of adenine in this class of helicases.