. Author manuscript; available in PMC: 2010 Mar 15.

Published in final edited form as: Physiol Rev. 2005 Jan;85(1):319–371. doi: 10.1152/physrev.00051.2003

TABLE 2.

Properties of K⁺ channels in the kidney

Tubule/Species	Location	γ	P_o	Voltage	Regulation	Reference Nos.
Proximal/rabbit	BL	54/10 pS* (127/127K)	0.06	Depolarization	Unknown	426
	BL	41/11pS^† (145/4.7K)	0.3–0.4	Unknown	Not sensitive to Ca²⁺	260
	BL	50–61/17 pS^† (150/5K)	0.15–0.20	Depolarization	pH, taurine ATP	35, 260, 405, 563
	BL	12/? PS^† (150/140K)	0.67	Unknown	Unknown	405
	AP	33/10 pS^† (145/4.7K)	Unknown	Unknown	Unknown	171
	AP	200/200 pS* (140/140K)	<0.01	Depolarization	pH, Ca²⁺	380
	AP	42/42 pS* (140/140K)	0.5	Unknown	Unknown	380
	Unknown	138/225 pS^† (150/4.7K)	<0.01	Unknown	Stretch, Ca²⁺	262
Proximal/mouse	AP	63/63 pS^† (145/4.7K)	Unknown	Unknown	Unknown	171
Proximal/Necturus	BL	31/? pS^† (100/2.5K)	0.01	Hyperpolarization	Unknown	261
	BL	36/36 pS* (70/70K)	0.02	Hyperpolarization	Stretch	468
	BL	24.5/3.7 pS^† (95/2.5K)	0.4	Unknown	PKA, PKC, pH, ATP	367
	AP	30/? pS^† (100/2.5K)	0.01	Depolarization	Unknown	261
Proximal/frog	BL	30/6 pS* (100/100K)	0.2	Depolarization	Unknown	218
	BL	30/29 pS^† (100/100K)	0.03	Hyperpolarization	Stretch	260
Macula densa/rabbit	AP	41/? pS^† (140/5K)	0.8	Unknown	pH, Ca²⁺ (inhibition)	221
TAL/rabbit (culture)	BL	35/7 pS^† (140/5K)	0.2	Unknown	pH	222
	AP	146/146 pS* (140/140K)	0.01	Depolarization	AA, Ca²⁺	172
TAL/rat and mouse	BL	41/10 pS	0.5	Depolarization	20-HETE, low pH_i	183, 431
TAL/rat and rabbit	AP	30–35/10 pS^† (140/5K)	0.9	Voltage independent	PKA, ATP	504, 599
TAL/rat	AP	70–75/19 pS* (145/4.2K)	0.4	Depolarization	PKA, PKC, pH, AA, cGMP, CO, ATP	49, 589
Diluting tubule/frog	AP	26/10 pS* (100/100K)	0.6	Depolarization	pH	222
DCT/rabbit	BL	48–60/? pS^† (130//5K)	Unknown	Unknown	pH	545
CCD (principal cell)/rat	AP	35–40/12 pS* (140/140K)	0.9	Slightly activated by depolarization	PKA, PKC, AA, ATP, Mg²⁺	153, 324, 478, 598
	AP	>?/110 pS^† (5/5K)	0.01	Depolarization	pH, Ca²⁺	152, 207, 220, 525
	BL	18/5 pS* (140/140K)	0.5	NO	PKG, pH	605
	BL	85/? pS* (140K/140K)	0.05	Hyperpolarization	PKA, pH	605
	BL	148/? pS* (145/3.6K)	0.6	Unknown	PKG, NO, pH	208, 209
	BL	67/? pS^† (145/3.6K)	Unknown	Unknown	PKG, NO, pH	208, 209

The channel conductance (γ) is denoted as inward/outward. The K⁺ concentrations (mM) are shown as pipette/bath solution. The patch-clamp configurations are indicated as for inside-out patch (*) or as for cell-attached patches (^†). BL and AP are basolateral membrane and apical membrane, respectively. See text for other definitions.