Table 1.

Effects of ischemia-hypoxia and ischemia-hyperoxia in the fronto-parietal cortex of young rats

		Ischemia-hypoxia		Ischemia-hyperoxia
Metabolite	Control	Right	Left	Right	Left
Alanine	0.66 ± 0.05	0.60 ± 0.03	0.66 ± 0.09	0.39 ± 0.07*	0.60 ± 0.08
Choline	3.74 ± 0.22	3.47 ± 0.13	3.88 ± 0.15	3.73 ± 0.26	3.58 ± 0.16
Creatine	10.99 ± 0.50	11.90 ± 0.10	12.78 ± 0.75	11.44 ± 0.65	11.43 ± 0.44
GABA	2.16 ± 0.11	1.40 ± 0.08**	1.67 ± 0.34	1.53 ± 0.28*	1.88 ± 0.28
Glutamate	14.44 ± 0.45	13.88 ± 0.45*	15.96 ± 0.93	13.78 ± 0.80	13.98 ± 0.70
Lactate	11.88 ± 0.28	15.18 ± 0.29**	17.01 ± 1.00**	13.55 ± 1.10*	13.93 ± 0.23**
Myo-inositol	4.98 ± 0.62	6.47 ± 0.80	7.36 ± 0.40*	6.74 ± 0.26*	5.63 ± 0.24
N-acetylaspartate	10.29 ± 0.16	10.33 ± 0.40	12.08 ± 0.50**	10.41 ± 0.65	10.64 ± 0.60

Concentrations of metabolites (mmol/kg w/w) in young rats, under normoxic condition (control), ischemia-hypoxia, and ischemia-hyperoxia. Data are means ± SE (n = 10 rats/group). Values, determined by proton MRS as outlined in the Methods, are given for the right (ipsilateral to cerebral ischemic injury) and left (contralateral) hemisphere. *P < 0.05 and **P < 0.01 compared with controls.