Table 3.

Effects of ischemia-hypoxia and ischemia-hyperoxia in the occipital cortex of young rats

		Ischemia-hypoxia		Ischemia-hyperoxia
Metabolite	Control	Right	Left	Right	Left
Alanine	0.64 ± 0.04	0.76 ± 0.08	0.73 ± 0.19	0.73 ± 0.02	0.50 ± 0.04
Choline	3.75 ± 0.05	3.59 ± 0.06	3.88 ± 0.23	4.34 ± 0.25	4.32 ± 0.29
Creatine	10.64 ± 0.10	11.81 ± 0.25**	12.08 ± 0.61	12.97 ± 0.60*	13.21 ± 1.00*
GABA	1.72 ± 0.21	1.76 ± 0.20	2.06 ± 0.54	2.52 ± 0.50*	2.02 ± 0.28
Glutamate	14.55 ± 0.18	14.91 ± 0.29	15.58 ± 1.50	16.17 ± 0.80*	16.02 ± 0.60*
Lactate	12.10 ± 0.51	16.56 ± 0.49***	17.87 ± 0.33***	16.03 ± 1.20**	15.73 ± 0.85**
Myo-inositol	5.67 ± 0.08	8.56 ± 0.40*	8.18 ± 1.14*	8.42 ± 0.90**	8.22 ± 0.80**
N-acetylaspartate	10.15 ± 0.21	11.01 ± 0.62	11.47 ± 0.85	11.85 ± 0.41	11.53 ± 0.44

Concentrations of metabolites (mmol/kg w/w) in young rats, under normoxic condition (control), ischemia-hypoxia, and ischemia-hyperoxia. Data are means ± SE (n = 10 rats/group). Values, determined by proton MRS as outlined in the Methods, are given for the right (ipsilateral to cerebral ischemic injury) and left (contralateral) hemisphere. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with controls.