Table 4.

Effects of ischemia-hypoxia and ischemia-hyperoxia in the occipital cortex of aged rats

		Ischemia-hypoxia		Ischemia-hyperoxia
Metabolite	Control	Right	Left	Right	Left
Alanine	0.61 ± 0.06	0.72 ± 0.03	0.85 ± 0.21	0.88 ± 0.07*	0.57 ± 0.12
Choline	3.50 ± 0.14	3.61 ± 0.07	3.74 ± 0.23	3.94 ± 0.36	3.72 ± 0.07
Creatine	10.53 ± 0.37	10.86 ± 0.24	10.76 ± 0.31	11.31 ± 0.90	11.32 ± 0.46
GABA	1.86 ± 0.24	2.02 ± 0.13	2.11 ± 0.59	3.16 ± 0.60*	2.25 ± 0.33
Glutamate	13.89 ± 0.51	13.73 ± 0.21	13.93 ± 0.46	13.71 ± 1.30	14.06 ± 0.26
Lactate	12.82 ± 0.49	16.12 ± 0.44***	16.37 ± 0.53***	15.53 ± 0.48**	15.69 ± 0.60**
Myo-inositol	6.55 ± 0.18	7.06 ± 0.35	7.76 ± 0.85*	7.63 ± 0.75	7.12 ± 0.33
N-acetylaspartate	9.98 ± 0.36	10.48 ± 0.30	10.87 ± 0.34	10.36 ± 0.60	10.14 ± 0.38

Concentrations of metabolites (mmol/kg w/w) in aged rats, under normoxic condition (control), ischemia-hypoxia, and ischemia-hyperoxia. Data are means ± SE (n = 10 rats/group). Values, determined by proton MRS as outlined in the Methods, are given for the right (ipsilateral to cerebral ischemic injury) and left (contralateral) hemisphere. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with controls.