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Effect of paclitaxel and SB-T-1216 at death-inducing concentrations on the DNA histogram of drug-sensitive MDA-MB-435 and drug-resistant NCI/ADR-RES cells. Control cells were incubated without taxane. After 24 h of incubation, the cells were stained with propidium iodide (see Materials and Methods) and analyzed by flow cytometry.
