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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Anticancer Res. 2009 Aug;29(8):2951–2960.

Figure 5.

Figure 5

Effect of paclitaxel and SB-T-1216 at death-inducing concentrations on caspase activities in drug-sensitive MDA-MB-435 and drug-resistant NCI/ADR-RES cells. Control cells were incubated without taxane. After 24 h of incubation, the activity of caspase-3 (A), -9 (B), -2 (C) and -8 (D) were measured as the absorbance of the cleaved product of a respective chromogenic substrate at 405 nm, employing a commercial colorimetric kit (see Materials and Methods). Each column represents the mean of 2 experimental values ± SEM. *P<0.05, **P<0.01 when comparing with control values.