Table 1. Numerical values for memory T cells in mice and humans.
Parameter Values | |||||||
Human | Mouse | ||||||
Parameter | Units | IL-15 | IL-7 | Refs | IL-15 | IL-7 | Refs |
1/102 | 1/68 | [19] | 1/17 | 1/10 | [20] | ||
cells | [23], [19] | [19] | |||||
cells/day | 0 | [16], [19] | 0 | [19] |
The values of for IL-7 are the sum of naive and memory CD and naive CD T cells. For humans the fraction of cell types in the blood was taken from Vrisekoop [19] and extrapolated to the total body using total cell numbers from Ganusov [23]. For mice, cell numbers in the spleen were taken from Vrisekoop [19] and extrapolated to whole body based on estimates of naive CD8 T cells in the whole body. The value for mice is taken from measurements of specific memory attrition, while for humans it is estimated from thymic output. Because we are interested in attrition rates the indirect measure provides better modeling accuracy.