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. 2010 Mar 16;5(3):e9701. doi: 10.1371/journal.pone.0009701

Figure 3. Skin phenotype in PPARβ/δ TG mice twenty days after GW501516 (GW) administration for twenty days.

Figure 3

(a–c) Gross morphology, (d–e) H&E histology of control mice not treated with GW (d), or fourteen days after induction (e–g). Magnification 200× (d,e) or 400× (f). The white arrowhead in (f) denotes the granular layer. (g) Immunostaining for Ki67 of skin from PPARβ/δ TG mice maintained in the absence (left) or presence (right) of GW. Magnification 200×. (h) Induction of skin disease by topical application of either 0.3% of indole-3-carbinole (I3C, left) or I3C plus 0.3% GW501516 once daily to shaved abdominal skin. Gross macroscopic phenotype (top) and H&E histology of treated skin (bottom) was documented 10 days after beginning of treatment.