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. 2010 Mar 16;5(3):e9706. doi: 10.1371/journal.pone.0009706

Figure 4. Sociability is not altered in GSK3 knockin mice.

Figure 4

A. GSK3 knockin mice lack serine-phosphorylation of GSK3 (PS-GSK3) on serine-21 of GSK3α and on serine-9 of GSK3β, which is evident in wild-type mice, as reported previously [27], [38]. Total GSK3 levels are equivalent in GSK3 knockin mice and wild-type mice. B. Mean total time spent in each chamber during the sociability period. Wild-type (WT) (n = 7) mice and GSK3 knockin (KI) (n = 10) mice spent significantly more time in Chamber 1, the chamber with S1, compared to empty Chamber 2 or Chamber 3 with the wire enclosure only. * p<0.05 comparing time spent in Chamber 1 with Chambers 2 and 3. C. Social approach, the total number of nose contacts by the test mouse with S1, was equivalent for untreated WT and KI mice. D. There was no difference in social interaction between WT and KI mice.