Table 1.

Comparison of pharmacokinetic parameters of gemcitabine (GEM) in plasma between administraion of GEM alone and GEM+S1

	Cmax (ng/ml)	AUCinf (hXng/ml)	T1/2 (h)
Day 1	15833 ± 2477	8467 ± 1092	0.12 ± 0.033
(GEM alone)
Day 15	14924 ± 5828	8384 ± 2915	0.153 ± 0.069
(GEM+S-1)
P-value	0.604	0.7406	0.1594

GEM was intravenously given at a dose of 800 mg/m2. S-1 was orally given at a dose of 30 mg/m2.

Cmax, maximum plasma concentration;

AUCinf, area under plasma concentration-time curve from time zero to infnite time; T1/2, elimination half-life.

Titers are expressed as means ± SD (n = 6). P-values were examined by two-sided paired t-test after log-transformation.