Table 2.
Percentages of patients showing positive immunohistochemical reactions to NAIP, Survivin and XIAP in normal prostate (NP), benign prostatic hyperplasia (BPH), prostatic carcinoma (PC) average optical densities of immunostaining in positive patients.
| NAIP | SURVIVIN | XIAP | ||||
|---|---|---|---|---|---|---|
| Prostates (no.) | Positive cases (%) | Optical density | Positive cases (%) | Optical density | Positive cases (%) | Optical density |
| Normal (20) | 0 | --- | 0 | --- | 20 | 6.96 ± 1.6a |
| BPH (35) | 60.6 | 11.23 ± 2.9a | 9.1 | 8.4 ± 1.51a | 27.27 | 13.42 ± 0.59b |
| PIN | ||||||
| Low grade PIN (12) | 0 | ---- | 0 | --- | 25 | 9.6 ± 1.21c |
| High grade PIN (15) | 60 | 18.49 ± 2.02b | 20 | 17.46 ± 1.57b | 33.3 | 16.93 ± 1.73d |
| PC | ||||||
| Low Gleason (21) | 56.52 | 17.4 ± 1.96b | 21.7 | 17.48 ± 1.53b | 17.39 | 17.79 ± 1.55d |
| Medium Gleason (51) | 58.82 | 18.25 ± 2.02b | 13.72 | 17.66 ± 1.6b | 39.21 | 16.64 ± 1.31d |
| High Gleason (21) | 66.6 | 17.28 ± 2.46b | 28.57 | 21.59 ± 1.35c | 23.8 | 16.38 ± 1.03d |
Average optical densities were evaluated only in patients showing positive immunoreactions. Statistical analysis refers to each antibody separately. Values denoted by different superscripts are significantly different from each other. Significance was determined by the one way ANOVA test at p ≤ 0.05, by multiple pairwise comparisons (GraphPad PRISMA 3.0 computer program).