Table 2.
ThinPrep diagnosis in relation to HPV DNA detection by HC2 or PCR
| HC2 | WNL | ASCUS | LSIL | HSIL | SCC | AdenoCa | Total |
|---|---|---|---|---|---|---|---|
| HC2 + | 105 | 45 | 93 | 8 | 9 | 0 | 260 |
| Negative | 924 | 56 | 26 | 2 | 1 | 1 | 1010 |
| Total | 1029 | 101 | 119 | 10 | 10 | 1 | 1270 |
| PCR | WNL | ASCUS | LSIL | HSIL | SCC | AdenoCa | Total |
| HPV X | 159 | 38 | 30 | 0 | 0 | 0 | 227 |
| HPV 6 | 10 | 4 | 9 | 1 | 0 | 0 | 24 |
| HPV 11 | 0 | 13 | 13 | 1 | 0 | 0 | 27 |
| HPV 16 | 0 | 2§ | 3 | § | 5§ | 0 | 10 |
| HPV 18 | 0 | 8§ | 5 | § | 1§ | 1 | 15 |
| HPV 31 | 1 | 1§ | 2 | § | § | 0 | 4 |
| HPV 33 | 10 | § | § | § | § | 0 | 10 |
| Multiple HPV types§ | 5 | 20 | 43§ | 8§ | 4§ | 0 | 80 |
| PCR + | 185 | 86 | 105 | 10 | 10 | 1 | 397 |
| Negative | 844 | 15 | 14 | 0 | 0 | 0 | 873 |
| Total | 1029 | 101 | 119 | 10 | 10 | 1 | 1270 |
Abbreviations: HC2: Hybrid Capture 2; HPV: Human Papillomavirus; WNL: Within Normal Limits; Hyperk: Hyperkeratosis; ASCUS: Atypical Squamous Cells of Undetermined Significance; LSIL: Low-grade Squamous Intraepithelial Lesion;
HSIL: High-grade Squamous Intraepithelial Lesion; SCC: Squamous Cell Carcinoma; AdenoCa: Adenococarcinoma
§Denotes the presence of mixed infections that are summarized under multiple HPV types. Nine HPV 16 mixed infections had LSIL, six had HSIL and four SCC. Twenty-seven HPV 18 mixed infections had LSIL, five had HSIL and three SCC. Nine HPV 31 mixed infections had LSIL, one had HSIL and two SCC. Seven HPV 33 mixed infections had LSIL, two had HSIL and three SCC.