Table 4.

Sensitivity, specificity, positive and negative predictive values and likelihood ratios of the various methods

	No. positive	Sens ≥ CIN2	Spec ≥ CIN2	PPV ≥ CIN 2	NPV ≥ CIN 2	PLR ≥ CIN 2	NLR ≥ CIN2
ThinPrep Pap ≥ ASCUS	241/1270 18.9%	26/26 100%	1029/1244 82.7%	26/241 10.8%	1029/1029 100%	5.8	0
ThinPrep Pap ≥ LSIL	140/1270 11%	23/26 88.5%	1127/1244 90.6%	23/140 16.4%	1127/1130 99.7%	9.4	0.13
ThinPrep Pap ≥ HSIL	21/1270 1.7%	21/26 80.8%	1244/1244 100%	21/21 100%	1244/1249 99.6%	∞	0.19
HC2 (+) ALL	260/1270 20.4%	19/26 73.1%	1003/1244 80.6%	19/260 7.3%	1003/1010 99.3%	3.8	0.21
HC2 (+) HR only	185/1270 14.6%	19/26 73.1%	1078/1244 86.7%	19/185 10.3%	1078/1085 99.4%	5.5	0.31
HPV PCR (+)	397/1270 31.3%	26/26 100%	873/1244 70.2%	26/397 6.5%	873/873 100%	3.4	0
HPV PCR (+) 16/18/31/33	109/1270 8.6%	21/26 80.8%	1156/1244 92.9%	21/109 19.3%	1156/1161 99.6%	11.4	0.21
	No. positive	Sens ≥ CIN3	Spec ≥ CIN 3	PPV ≥ CIN 3	NPV ≥ CIN 3	PLR ≥ CIN 3	NLR ≥ CIN 3
ThinPrep Pap ≥ ASCUS	241/1270 18.9%	15/15 100%	1029/1255 82%	15/241 6.2%	1029/1029 100%	5.6	0
ThinPrep Pap ≥ LSIL	140/1270 11%	14/15 93.3%	1129/1255 90%	14/140 10%	1129/1130 99.9%	9.3	0.07
ThinPrep Pap ≥ HSIL	21/1270 1.7%	14/15 93.3%	1248/1255 99.44	14/21 66.7	1248/1249 99.9%	166.6	0.067
HC2 (+) ALL	260/1270 20.4%	11/15 73.3%	1006/1255 80.2%	11/260 4.2%	1006/1010 99.6%	3.7	0.33
HC2 (+) HR only	185/1270 14.6%	11/15 73.3%	1081/1255 86.1%	11/185 5.9%	1081/1085 99.6%	5.3	0.31
HPV PCR (+)	397/1270 31.3%	15/15 100%	873/1255 69.6%	15/397 3.8%	873/873 100%	3.2	0
HPV PCR (+) 16/18/31/33	109/1270 8.6%	15/15 100%	1161/1255 92.5%	15/109 13.8%	1161/1161 100%	13.4	0

HSIL: High-grade squamous intraepithelial lesion, Sens: sensitivity, Spec: specificity, PPV: Positive predictive value, NPV: Negative predictive value, PLR: positive likelihood ratio, NLR: negative likelihood ratio