Table 2.
Suture closure in Apert syndrome mice
| Fusion | ||||
|---|---|---|---|---|
| Sutures | +/P253R (n = 10) |
+/+ littermate (n = 7) |
+/S252W (n = 8) |
+/+ littermate (n = 12) |
| closed/total* | closed/total | closed/total | patent/closed | |
| Coronal (bi- or unicoronal) | 9/10 | 0/7 | 7/8 | 0/12 |
| Zygomatic-maxillary | 10/10 | 0/7 | 7/8 | 0/12 |
| Maxilla-premaxillary | 10/10 | 0/7 | 8/8 | 0/12 |
| Inter-premaxillary | 0/10 | 7/7 | 1/8 | 11/12 |
| Inter-palatine | 0/10 | 2/7 | 0/8 | 3/12 |
| Maxillary-palatine | 1/10 | 4/7 | 7/8 | 5/12 |
* The observation of "closed" varies from simple bridging across the suture to complete closure. Closure can be unilateral or bilateral. Because these are P0 mice, it should be recognized that suture closure is a dynamic process and will vary given the age of the mice observed.