Figure 2.

Ovulation rate following doxorubicin treatment. Female mice were injected with doxorubicin or with saline. Ovulation was induced by injecting the mice with 5 IU hCG 48 hours after administration of 10 IU of PMSG. The mice were sacrificed 16-17 hours after hCG administration at a time coinciding with either 48 hours, one week or one month after the doxorubicin or saline injections. The number of ovulated oocytes was recorded. Bars represent percent of ovulated control oocytes (mean ± SEM), (*)-significantly different from control value (P < 0.05); N = number of mice.