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Three-dimensional structures of Plasmodium DHFRs: (A) solved crystal structure of P. falciparum DHFR complexed with WR99210 (red ball and stick) and NADPH (blue ball and stick); (B) solved crystal structure of P. vivax DHFR complexed with pyrimethamine (red ball and stick) and NADPH (blue ball and stick); (C) homology model of P. malariae DHFR, and (D) homology model of P. ovale DHFR.
