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. Author manuscript; available in PMC: 2011 Mar 15.
Published in final edited form as: Chem Res Toxicol. 2010 Mar 15;23(3):447–454. doi: 10.1021/tx9003775

Figure 2. Chlorination of Tyr192 and Met oxidation are necessary for depriving apoA-I of its cholesterol efflux activity.

Figure 2

(A) [3H]cholesterol efflux was measured in ABCA1-transfected BHK cells incubated with the indicated concentrations of wild-type (WT) or Tyr192Phe mutant apoA-I. (B) WT or Tyr192Phe mutant apoA-I was oxidized by the MPO-H2O2-chloride system (25:1, mol/mol, H2O2/apoA-I). Where indicated, apoA-I was incubated with the methionine sulfoxide reductase PilB. Reproduced with permission from (41).