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. Author manuscript; available in PMC: 2011 Mar 15.
Published in final edited form as: Chem Res Toxicol. 2010 Mar 15;23(3):447–454. doi: 10.1021/tx9003775

Figure 5. Mutation of Met148 to Leu protects apoA-I from the oxidative loss of LCAT activity.

Figure 5

rHDL was prepared with wild-type (WT) or mutated apoA-I. (A) LCAT activity of Met-mutated rHDLs exposed to a 30-fold molar ratio of HOCl. (B) LCAT activity of Met-, Trp-, and Tyr-mutated rHDLs exposed to a 40-fold molar ratio of HOCl. DeltaW (ΔW), deletion all four Trp residues of apoA-I. 3M/L, Met86Leu/Met112Leu/Met148Leu mutant apoA-I. Reproduced with permission from (56).