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. Author manuscript; available in PMC: 2011 Mar 15.
Published in final edited form as: Chem Res Toxicol. 2010 Mar 15;23(3):447–454. doi: 10.1021/tx9003775

Figure 7. Oxidation of apoA-I by MPO inhibits two steps of reverse cholesterol transport.

Figure 7

Oxidation of lipid-free apoA-I by MPO impairs the protein’s ability to transport cellular cholesterol by the ABCA1 pathway. Oxidation of lipid-associated apoA-I by MPO impairs its ability to activate LCAT.