Table 2.

Creation of the Quantitative Adverse Reaction Knowledgebase

Step	Process Details	Example
Medication Selection	Identified 250 commonly prescribed medications based on national and local pharmacy dispensing data	Lisinopril
SPL Extraction	Retrieved Structure Product Label for each drug. Extracted side-effect and frequency data	“Taste disturbances occurred rarely in patients on Lisinopril”
Data Standardization	Standardized side-effects to MedDRA preferred terms. Standardized frequency data to a simplified numeric value (Rxplore Score).	“Taste Disturbance” → “Dysgeusia” “Rarely” → 0.3
Storage in Knowledgebase	Stored drug name, coded effect, and Score for 16,340 drug-effect pairs	Lisinopril | Dysgeusia | 0.3