Table 4.

Clinical–pathological correlation using UK ADC data on patients with severe cognitive impairments, N = 237 total

Number of clinical core features of DLB present	0	1	2	3
N (total 237)	194	32	10	1
N with pure DLB (%)	10 (5)	2 (6)	1 (10)	0
N with AD + DLB (%)	27 (14)	5 (16)	2 (20)	1 (100)
N with pure AD (%)	118 (61)	20 (63)	5 (50)	0

In patients with severe cognitive impairments (mean final MMSE score = 11.4 ± 8.1), the presence of the core symptoms of DLB (visual hallucinations, extrapyramidal signs, and fluctuating cognition) do not predict the presence of DLBs. The large majority of these patients were not diagnosed clinically with DLB despite the presence of the clinical features, because the symptoms started in late stages of the disease. The definitions of “pure DLB”, “pure AD”, or “AD + DLB” are based on neuropathological data as defined in Table 1