Figure 7. Stochastic puff model.

A: Puff duration (t_f) as a function of puff amplitude for experimental observations in Xenopus laevis oocytes (open circles) and stochastically simulated puffs obtained using model C_d (black squares and error bars correspond to mean values and standard deviations, respectively). B: Duration of the Ca²⁺ release as a function of the maximum Ca²⁺ current for stochastically simulated puffs obtained using model C_d (black circles) and C_i (open circles). C: Maximum released current (open circles) and averaged current (mean with black dots and standard deviation with vertical lines) released during the events as function of the number of channels in the cluster, N_p, obtained with simulations that use the C_d kinetic model. Superimposed in black, curves that correspond to the I~Np and I~N_p^1/2 scalings for N_p< 22 and N_p> 22, respectively. In B and C, the maximum released current was obtained from a smoothed version of the simulated I(t).