Table 2.
Target | Compound(s) | Mechanism |
---|---|---|
PI3-K | CAL-101 | Small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class IA PI3-K (clinicaltrials.gov, NCT00710528) |
PI-103 | Small molecule inhibitor of PI3-K and mTOR 135. | |
Akt | Perifosine | Decreases plasma membrane localization of Akt and its phosphorylation 136 (clinicaltrials.gov, NCT00391560). |
GSK21110183 | Oral small molecule Akt inhibitor (clinicaltrials.gov, NCT00881946). |
|
mTOR | Sirolimus (Rapamycin) Temsirolimus Everolimus (RAD 001) Deforolimus |
Directly suppresses mTOR when bound to FKBP12 79, 90, 93, 96, 137. |
PIM | SGI-1776 | Small molecule inhibitor of tyrosine kinase (clinicaltrials.gov, NCT00848601). |