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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: J Allergy Clin Immunol. 2010 Feb 11;125(3):550–558. doi: 10.1016/j.jaci.2009.11.005

Figure 2.

Figure 2

Hypothesized mechanisms by which glucocorticoid resistance could occur. (A): Glucocorticoid binding to the GR induces molecular rearrangement of the GR-HSP90 heterocomplex and promotes GR nuclear translocation, homodimerization, and DNA-binding. (B): This process can be modulated by GR/NF-κB interactions, directly by affecting transactivation (GRE-mediated) as well as transrepression of GR functions. Indirect inhibition of the GR function maybe achieved by transcription factor “tethering”.